期刊
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
卷 28, 期 3, 页码 223-230出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2005.01.004
关键词
everted sleeves; follicle-associated epithelium; goats; intestinal uptake; Mycobacterium paratuberculosis; M cells; Peyer's patches; paratuberculosis
The main lesions of paratuberculosis in ruminants are in the small intestine. Previous studies have shown that the bacterium enters the small intestine through M cells found in the follicle-associated epithelium lining the domes of the Peyer's patches. The everted sleeve method, devised for the in vitro study of intestinal absorption, was used in this study to investigate the uptake of Mycobacterium avium subsp. paratuberculosis in goat intestine. Everted small intestinal sleeves of goat kids, prepared from areas with and without Peyer's patches, were incubated for 60 min in 3 H-labeled bacterial solution. The results of this study imply that the bacteria can enter the intestinal mucosa of the jejunum, both in areas with and without Peyer's patches. These findings indicate, therefore, that M. avium subsp. paratuberculosis bacteria not only enter through M cells but also through enterocytes. (c) 2005 Published by Elsevier Ltd.
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