期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 45, 期 5, 页码 555-563出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0091270005274550
关键词
dabigatran etexilate; direct thrombin inhibitor; pharmacokinetics; total hip replacement; venous thromboembolism
Dabigatran etexilate is an oral low-moleculor-weight direct thrombin inhibitor. Following oral administration, dabigatran etexilate is rapidly converted to its active form, dabigatran. The authors investigated the absorption, distribution, and elimination of a single 150-mg dose capsule formulation of dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. In on open-label, 3-way crossover study, dabigatran etexilate was administered to 18 male volunteers in the fasted state, after administration of food and with coadministration of the proton pump inhibitor, pantoprazole. In a subsequent multicenter, open-label study, 59 patients received a single dose of dabigatran etexilate, administered 1 to 3 hours following total hip replacement, In healthy volunteers, food had no effect on the extent of absorption of dabigatran etexilate, although there was reduced interindividual variability for dabigatran maximum plasma concentration and AUC(0-infinity). A decrease in the mean dabigatran AUC(0-infinity) (904 to 705 ng center dot h/mL) occurred with coadministration of pantoprazole, In patients undergoing total hip replacement, immediate onset of absorption was seen with the maximum plasma concentration of dabigatran occurring after 6 hours, The AUC(0-24) of dabigatran was 88% of the steady-state AUC using a preliminary tablet formulation and 106% of that seen in the healthy volunteer study, Compared with healthy volunteers, the postoperative profile was flattened with delayed peak concentrations, In summary, administration of the dabigatran etexilate capsule with food has no effect on the extent of dabigatran absorption, with a moderate decrease when coadministered with pantoprazole. Adequate plasma concentrations of dabigatran were seen with early postoperative administration of the dabigatron etexilate capsule. These pharmaco-kinetic characteristics confirm the suitability of this oral solid dosage form for use in future clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据