期刊
NATURE GENETICS
卷 37, 期 5, 页码 471-477出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1545
关键词
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资金
- NICHD NIH HHS [P01 HD039691] Funding Source: Medline
Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a variety of experimental expertise and so is unsuitable for genome-scale analysis. Here we used microarray profiles of mutants as phenotypes for epistasis analysis. Considering genes that regulate activity of protein kinase A in Dictyostelium, we identified known and unknown epistatic relationships and reconstructed a genetic network with microarray phenotypes alone. This work shows that microarray data can provide a uniform, quantitative tool for large-scale genetic network analysis.
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