期刊
COGNITIVE BRAIN RESEARCH
卷 23, 期 2-3, 页码 277-286出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cogbrainres.2004.10.019
关键词
face processing; visual ERP; schizophrenia; psychosis; facial expression; face recognition; N170
Patients with schizophrenia are known to have behavioral deficits in recognizing faces and facial expressions. However, the ability to process simple visual stimuli appears to be intact in first-episode psychosis. The aim of this study was to examine complex visual processing, especially the event-related potentials (ERPs) elicited by human faces, in early psychosis. Never-medicated patients in acute psychosis (n = 18) were compared with healthy controls (n = 19). Photographs of human faces were presented in a classic oddball paradigm requiring a motor response to a smiling face. Cerebral sources of ERPs were analyzed of the averaged responses, using minimum none estimates, and dipole models. Face-sensitive response at 145 ms after the face stimuli was of significantly higher amplitude in our never-medicated patients, and the activity distribution between the groups was clearly different. At the early phase of a psychotic illness, these alterations in face-related neuronal network processes represent perceptual disturbance in psychosis, possibly including state and trait, as well as potential physiological compensatory features. (c) 2004 Elsevier B.V. All rights reserved.
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