期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 45, 期 5, 页码 519-528出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0091270005274551
关键词
Alzheimer's disease; galantamine; memantine; drug interaction; pharmacokinetics
To evaluate the effect of multiple doses of memantine on the pharmacokinetics of galantomine and to assess the safety and tolerability of galantamine with adjunctive memantine treatment, an open-label, single-center, drug interaction study was conducted in 16 healthy adults. Subjects received an 8-mg dose of galantamine extended release once daily during week 1 and a 16-mg dose of galantamine extended release once daily during week 2. During weeks 3 and 4, they received a 16-ma dose of galantamine extended release once daily and a 10-mg dose of memantine twice daily, except on days 1 and 2 of week 3, when memantine was given as 10 mg once daily. The pharmacokinetic profile and parameters of galantamine at steady state were similar after administration of a 16-mg dose of galantamine once daily alone and after administration with a 10-mg dose of memantine twice daily. Galantamine 16 mg once daily with adjunctive memantine 10 mg twice daily was well tolerated and safe in healthy subjects.
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