期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 201, 期 9, 页码 1479-1486出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050473
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资金
- NCI NIH HHS [CA78846, R01 CA078846] Funding Source: Medline
- NIAMS NIH HHS [R01 AR050770, R01 AR050770-01] Funding Source: Medline
- PHS HHS [U19A1057234-02] Funding Source: Medline
Systemic onset juvenile idiopathic arthritis (SoJIA) encompasses SIM 10% of cases of arthritis that begin in childhood. The disease is unique in terms of clinical manifestations, severity of joint involvement, and lack of response to tumor necrosis factor blockade. Here, we show that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs). Upon activation, SoJIA PBMCs release large amounts of IL-1beta. We administered recombinant IL-1 receptor antagonist to nine SoJIA patients who were refractory to other therapies. Complete remission was obtained in seven out of nine patients and a partial response was obtained in the other two patients. We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease.
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