An efficient catalyst system for diaryl ether synthesis from aryl chlorides

The combination of 2-phosphino-substituted N-arylpyrroles or related indoles (cataCXium (R) P) and Pd(OAc)(2) allows for efficient cross-coupling reactions of aryl chlorides and phenols to give diaryl ethers. A variety of aryl and heteroaryl chlorides can be coupled with substituted phenols showing unprecedented catalyst turnover numbers. (c) 2005 Published by Elsevier Ltd.