期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 9, 页码 3095-3098出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm0501432
关键词
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A series of novel, disulfide-constrained human β-melanocyte stimulating hormone (β-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonist efficacy, and selectivity. The most promising of these, analogue 18, was further studied in vivo using chronic rat food intake and body weight models.
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