期刊
TETRAHEDRON LETTERS
卷 46, 期 19, 页码 3385-3389出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.03.085
关键词
proline-derived N-sulfonylcarboxamides; asymmetric catalysis; nitroso Diels-Alder; ketones; aldehydes
The proline-derived N-sulfonylcarboxamide-catalyzed direct enantioselective alpha-oxidation of ketones and aldehydes with nitrosobenzene is presented. The reactions proceed smoothly furnishing the corresponding alpha-aminoxylated compounds in good yields with up to > 99% ee. The proline-derived N-sulfonylcarboxamides were also found to be excellent catalysts for the direct enantioselective nitroso Diels-Alder-type reaction between nitrosobenzene and of alpha,beta-unsaturated cyclic ketones yielding the corresponding bicyclic Diels-Alder adduct products with tip to > 99% ee. The proline-derived N-sulfonylcarboxamides represent a readily available and highly modular novel type of organic catalyst. (c) 2005 Elsevier Ltd. All rights reservesd.
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