期刊
DRUG AND ALCOHOL DEPENDENCE
卷 78, 期 2, 页码 135-140出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2004.10.006
关键词
cocaine; MDMA; drug abuse; reinforcing efficacy; rhesus monkey
资金
- NIDA NIH HHS [DA-06634, DA-05934] Funding Source: Medline
The purpose of the present study was to compare the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to cocaine. Rhesus monkeys (n = 4) responded under a within-session, exponentially increasing, progressive-ratio (PR) schedule of cocaine reinforcement. Breaking point (BP) for the PR schedule was defined as the final response requirement completed before 2 h had elapsed without an injection delivered. Saline and doses of cocaine (0.003-0.3 mg/kg/injection) and MDMA (0.01-0.56 mg/kg/injection) were substituted for the training dose of cocaine for at least five consecutive sessions. Both cocaine and MDMA functioned as reinforcers, but self-administration of MDMA occurred at fewer doses and a significantly lower peak BP was obtained for MDMA. These data demonstrate that MDMA functions as a reinforcer, although its reinforcing efficacy appears to be less than that of cocaine. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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