The increasing attention directed towards nanobiological science requires high-resolution imaging tools for the liquid environment. We have been successful in recording molecular-resolution images of polydiacetylene in water with the frequency-modulation atomic force microscopy (FM-AFM). With the oscillation amplitude of a force-sensing cantilever reduced to 0.20 nm, we were able to overcome the large frequency noise due to the low Q-factor of cantilever resonance in water. We have obtained vertical and lateral resolutions of 10 pm and 250 pm, respectively. This method enables nondestructive imaging of soft biological samples with a load force on the order of 1 pN. (c) 2005 American Institute of Physics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据