期刊
NEUROLOGY
卷 64, 期 9, 页码 1618-1620出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000160397.81314.84
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The authors describe 12 neuroleptic-treated patients with dementia of various etiologies who showed CSF elevation of phosphorylated 14-3-3ζ and normal tau protein levels. This contrasted with elevated amounts of 14-3-3 γ, ε, and unphosphorylated ζ coupled to high tau protein levels in Creutzfeldt Jakob disease and negative 14-3-3 assay in drug-free patients with dementia. Characterization of CSF 14-3-3 isoforms and determination of tau protein level can help to distinguish different etiologies of dementia.
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