期刊
CURRENT BIOLOGY
卷 15, 期 9, 页码 833-838出版社
CELL PRESS
DOI: 10.1016/j.cub.2005.03.039
关键词
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资金
- NIGMS NIH HHS [GM54832-09] Funding Source: Medline
Heparan sulfate proteoglycans (HSPGs), a class of glycosaminoglycan-modified proteins, control diverse patterning events via their regulation of growth-factor signaling and morphogen distribution [1]. In C. elegans, zebrafish, and the mouse, heparan sulfate (HS) biosynthesis is required for normal axon guidance [2-4], and mutations affecting Syndecan (Sdc), a transmembrane HSPG, disrupt axon guidance in Drosophila embryos [5, 6]. Glypicans, a family of glycosylphosphatidylinositol (GPI)-linked HSPGs, are expressed on axons and growth cones in vertebrates, but their role in axon guidance has not been determined [7, 8]. We demonstrate here that the Drosophila glypican Daily-like protein (Dlp) is required for proper axon guidance and visual-system function. Mosaic studies revealed that Dip is necessary in both the retina and the brain for different aspects of visual-system assembly. Sdc mutants also showed axon guidance and visual-system defects, some that overlap with dip and others that are unique. dlp(+) transgenes were able to rescue some sdc visual-system phenotypes, but sdc(+) transgenes were ineffective in rescuing dip abnormalities. Together, these findings suggest that in some contexts HS chains provide the biologically critical component, whereas in others the structure of the protein core is also essential.
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