Interleukin-1 and interleukin-6 production in mice's lungs induced by 2, 3 meso-dimercaptosuccinic-coated magnetic nanoparticles

In the present study, we evaluated the effects of a water-based (physiological medium) magnetic fluid sample containing magnetite nanoparticles surface coated with a layer of 2, 3 meso-dimercaptosuccinic acid in mice. The animals were killed after times varying from 5 min to 24 h. Tissue analysis was made by light microscopy using hematoxilin and eosin (HE) staining and interleukin I and 6 immunohistochemistry. The results showed accumulation of nanoparticles in lungs after 30 min of sample administration, with inflammatory process associated to it. It also showed an increase in both interleukins expression, which confirms inflammatory response associated with magnetic nanoparticles. (c) 2005 American Institute of Physics.