期刊
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
卷 171, 期 10, 页码 1129-1135出版社
AMER THORACIC SOC
DOI: 10.1164/rccm.200406-837OC
关键词
air pollution; metal fume fever; particulate matter; ultrafine; zinc
资金
- NCRR NIH HHS [5 M01 RR00044] Funding Source: Medline
- NHLBI NIH HHS [HL65208-03] Funding Source: Medline
- NIEHS NIH HHS [P30 ES01247] Funding Source: Medline
- EAPO CDC HHS [EPA R-827354] Funding Source: Medline
Rationale: Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 μ m diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 μ m diameter). Objectives: We compared exposure-response relationships for respiratory, hematologic, and cardiovascular endpoints between ultrafine and accumulation mode zinc oxide particles. Methods: In a human inhalation study, 12 healthy adults inhaled 500 μ g/m(3) of ultrafine zinc oxide, the same mass of fine zinc oxide, and filtered air while at rest for 2 hours. Measurements and Main Results: Preexposure and follow-up studies of symptoms, leukocyte surface markers, hemostasis, and cardiac electrophysiology were conducted to 24 hours post-exposure. Induced sputum was sampled 24 hours after exposure. No differences were detected between any of the three exposure conditions at this level of exposure. Conclusions: Freshly generated zinc oxide in the fine or ultrafine fractions inhaled by healthy subjects at rest at a concentration of 500 μ g/m(3) for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.
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