期刊
NEUROIMAGE
卷 26, 期 1, 页码 195-205出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2005.01.019
关键词
DTI tractography; white matter; tract; parcellation; inner landmark; corpus callosum morphology; stroke
资金
- NCRR NIH HHS [RR15241] Funding Source: Medline
- NIA NIH HHS [R01 AG20012] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909] Funding Source: Medline
- NIDCD NIH HHS [R01 DC005375] Funding Source: Medline
Morphology of the corpus callosum (CC) at the mid-sagittal level has been a target of extensive studies. However, the lack of internal structures and its polymorphism make it a challenging task to quantitatively analyze shape differences among subjects. In this paper, diffusion tensor Imaging (DTI) and tract tracing technique were applied to incorporate cortical connectivity information to the morphological study. The CC was parcellated into six major subdivisions based on trajectories to different cortical areas. This subdivision was performed for eight normal subjects and one stroke patient. The parcellated CCs of the normal subjects were normalized for morphological analysis. When comparing the stroke patient to the normal population, we detected significant atrophy in the motor and sensory areas of the patient CC, in line with the clinical deficits. This approach provides a new tool to investigate callosal morphology and functional relationships. (c) 2005 Elsevier Inc. All rights reserved.
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