期刊
JOURNAL OF IMMUNOLOGY
卷 174, 期 10, 页码 5907-5914出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.10.5907
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Naturally occurring CD4(+)CD25(+) regulatory T (T,) cells, a component of the innate immune response, which play a key role in the maintenance of self-tolerance, have become the focus of numerous studies over the last decade. These cells inhibit the immune response in an Ag-nonspeciflic manner, interacting with other T cells. Much less is known about adaptive T-R cells, which develop in response to chronic antigenic stimulation, and act directly on professional and nonprofessional APG rendering them tolerogenic and able to elicit the differentiation of CD8(+) and CD4(+) T cells with suppressive activity. In this review, we will discuss data pertaining to the bidirectional interaction between Ag-specific T-R with APC and their clinical relevance.
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