期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 10, 页码 2575-2578出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.03.048
关键词
thiosemicarbazones; 4-thiazolidinones; Toxoplasma gondii
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. (c) 2005 Elsevier Ltd. All rights reserved.
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