期刊
CHEMICAL PHYSICS LETTERS
卷 407, 期 1-3, 页码 23-29出版社
ELSEVIER
DOI: 10.1016/j.cplett.2005.02.125
关键词
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MD simulation, to closely mimic a torsionally unconstrained single-molecule stretching experiment of dsDNA, uncovers three distinct force regimes, characterized by fast and slow elongation regions with a transition regime in between, where the alpha and gamma backbone torsion angles of the elongated double-stranded DNA find rapidly new stationary values. In the slow elongation regime DNA gradually looses its twist, collectively breaks all base-pair H-bonds and develops a remarkable base-stacked structure with the bases strongly tilted, forming a zipper-like stack on the major groove side, stabilized by the narrowing distance between the elongated strands, and by specific water interactions. (c) 2005 Elsevier B.V. All rights reserved.
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