期刊
AIDS
卷 19, 期 8, 页码 833-835出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aids.0000168980.74713.9e
关键词
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资金
- Medical Research Council [G0200000] Funding Source: Medline
- Medical Research Council [G0200000] Funding Source: researchfish
- MRC [G0200000] Funding Source: UKRI
Many clade C isolates of HIV-1 do not react with monoclonal antibody (MAb) 2G12, a broad-ranging human neutralizing MAb that recognizes high mannose carbohydrate groups attached to glycoprotein gp120. We reintroduced a partial and complete 2G12 epitope into a clade C background, HIV-1(CN54), and examined the antibody reactivity of the resulting recombinant molecules. Two glycosylation sites recovered 2G12 binding completely, but some binding was evident after the reintroduction of a single glycosylation site at Asn295.
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