期刊
BRITISH JOURNAL OF CANCER
卷 92, 期 10, 页码 1922-1926出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602557
关键词
small-molecule therapy; tyrosine kinase; EGFR mutation; breast cancer
类别
资金
- NCI NIH HHS [P30CA16058, P30 CA16059, P01CA97189, P30 CA016059, P30 CA016058, U54 CA113001, P50CA113001, P01 CA097189] Funding Source: Medline
Organ-specific differences in epidermal growth factor receptor ( EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
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