期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 57, 期 7, 页码 973-993出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2004.12.013
关键词
cathepsin K; cathepsin S; cysteine proteases; osteoporosis; arthritis; cysteine protease inhibitors
资金
- NIAMS NIH HHS [AR48669, AR46182] Funding Source: Medline
Human cysteine proteases of the papain family have been recognized as potential drug targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular matrix proteins, in particular collagens. The predominant expression of cathepsin K in osteoclasts has rendered the enzyme into a major target for the development of novel anti-resorptive drugs in osteoporosis whereas cathepsin S appears to be an attractive drug target candidate for various inflammatory diseases including rheumatoid arthritis. Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. This review will outline the rationale and recent progress for targeting cathepsins in arthritis and osteoporosis. (c) 2005 Elsevier B.V All rights reserved.
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