期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 57, 期 7, 页码 1049-1076出版社
ELSEVIER
DOI: 10.1016/j.addr.2004.12.011
关键词
bone-targeting; drug delivery; HPMA copolymer; hydroxyapatite; metalloproteinases (MMPs); cathepsin K; polyethylene glycol (PEG); osteoporosis; cancer bone metastasis; rheumatoid arthritis
资金
- NIGMS NIH HHS [GM069847-01] Funding Source: Medline
Musculoskeletal diseases such as osteoporosis are recognized as major public health problems worldwide. Many novel therapeutic agents have been identified for the treatment of these diseases. However, the majority of them are not specific to hard tissue, resulting significant toxicity. Bone-targeting drug delivery systems based on water-soluble polymers can specifically direct candidate drugs to bone thereby reducing side effects due to non-specific tissue interactions. Incorporation of a targeting moiety, a drug release mechanism, drug selection and optimization of the polymer carrier are all essential elements in the development of bone-targeting macromolecular therapeutics. Successful clinical application of this approach can significantly contribute to the development of treatments for many musculoskeletal diseases. (c) 2005 Elsevier B.V. All rights reserved.
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