期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 21, 页码 5225-5229出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0719-05.2005
关键词
two-photon; orexin; divided attention; rat; alpha 4 beta 2 nicotinic acetylcholine receptors; behavior
资金
- NIAAA NIH HHS [P50 AA015632, 1 P50 AA15632] Funding Source: Medline
- NIDA NIH HHS [R01 DA011717, DA11717] Funding Source: Medline
- NIMH NIH HHS [R37 MH017871, R01 MH017871, MH17871] Funding Source: Medline
Thalamic projections to prefrontal cortex are important for executive aspects of attention. Using two-photon imaging in prefrontal brain slices, we show that nicotine and the wakefulness neuropeptide hypocretin (orexin) excite the same identified synapses of the thalamocortical arousal pathway within the prefrontal cortex. Although it is known that attention can be improved when nicotine is infused directly into the midlayer of the prefrontal cortex in the rat, the effects of hypocretin on attention are not known. The overlap in thalamocortical synapses excited by hypocretin and nicotine and the lack of direct postsynaptic effects prompted us to compare their effects on a sustained and divided attention task in the rat. Similar to nicotine, infusions of hypocretin-2 peptide into the prefrontal cortex significantly improved accuracy under high attentional demand without effects on other performance measures. We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex.
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