期刊
ORGANIC LETTERS
卷 7, 期 11, 页码 2153-2156出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol050512o
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资金
- NIGMS NIH HHS [R01 GM028961, GM-28961] Funding Source: Medline
Synthesis of the first of a projected series of bryostatin analogues has been accomplished in 26 steps and 2.2% overall yield. In this letter, we detail two approaches to the structural core of these tricyclic macrolactone bryostatin analogues. The key features of the route include BITIP-catalyzed asymmetric allylation reactions and Mukaiyama aldol reactions, a chelation-controlled allylation, pyran annulation reactions, and macrolactonization.
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