期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1740, 期 2, 页码 147-154出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2004.12.009
关键词
carotenoid; beta-carotene; vitamin A; gene expression; functional genomics; model system
Carotenoids are highly bioactive dietary compounds that have the potential to have significant effects on human health. It is becoming increasingly clear that the various biological effects; that carotenoids exert could be driven via a number of different mechanisms. These include direct pro- and antioxidant effects, redox sensitive cell signalling, vitamin A signalling pathways and other as yet unidentified mechanisms. This article provides an overview of the known effects of carotenoids and discusses the use of model systems and functional genomic approaches further to elucidate their modes of action. (c) 2004 Elsevier B.V. All rights reserved.
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