期刊
JOURNAL OF VIROLOGY
卷 79, 期 12, 页码 7926-7932出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.12.7926-7932.2005
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资金
- NCI NIH HHS [R24 CA095823] Funding Source: Medline
We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs into virus particles were similar to those of wild-type virus. We propose that a threshold amount of M1 protein is needed for the assembly of viral components into an infectious particle and that budding is delayed in Mmut virus-infected cells until sufficient levels of M1 protein accumulate at the plasma membrane.
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