期刊
CANCER LETTERS
卷 223, 期 1, 页码 137-142出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.09.037
关键词
tissue inhibitor of matrix metalloproteinase-3 (TIMP-3); colorectal carcinoma; microsatellite instability (MSI); mismatch repair (MMR) deficiency; Sorsby fundus dystrophy (SFD)
类别
Methylation of promoter regions and frameshift mutations in microsatellites of the coding sequence (CDs) of genes are frequently associated with loss of expression in microsatellite instable (MSI) colorectal carcinoma. In a panel of 40 MSI and 24 microsatellite stable (MSS) colorectal tumours as well as six cultured colorectal carcinoma cell lines hypermethylation of the TIMP3-promoter was found in 28% of MSI and 25% of MSS tumours, respectively. Additionally, three MSI tumours and one cell line displayed instability of a C-7-repeat located in the CDs of the TIMP-3 gene. TIMP-3 fulfils all important criteria for being a target gene in the mutator pathway. Thus, TIMP-3 might be a factor of general importance for colorectal carcinogenesis. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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