期刊
NATURE REVIEWS DRUG DISCOVERY
卷 4, 期 6, 页码 461-467出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1754
关键词
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The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease-not target selection-are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.
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