期刊
NATURE REVIEWS GENETICS
卷 6, 期 6, 页码 507-512出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1619
关键词
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Gene targeting in mouse embryonic stem cells has become the 'gold standard' for determining gene function in mammals. Since its inception, this technology has revolutionized the study of mammalian biology and human medicine. Here I provide a personal account of the work that led to the generation of gene targeting which now lies at the Centre of functional genomic analysis.
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