期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 81, 期 5, 页码 378-384出版社
SPRINGER JAPAN KK
DOI: 10.1532/IJH97.04180
关键词
GATA-1; FOG; X-linked thrombocytopenia; megakaryoblastic leukemia; Down syndrome
类别
资金
- NHLBI NIH HHS [HL075705] Funding Source: Medline
GATA family transcription factors play essential roles in broad developmental settings. GATA-1, one of the hematopoietically expressed members, is required for normal erythroid and megakaryocytic differentiation. Over the past few years, mutations in the gene encoding GATA-1 have been linked to several human hematologic disorders, including X-linked dyserythropoietic anemia and thrombocytopenia, X-linked thrombocytopenia and beta-thalassemia, and Down syndrome acute megakaryoblastic leukemia. This review summarizes the role of GATA-1 during normal hematopoiesis and discusses how disease-associated mutations may affect its function. (c) 2005 The Japanese Society of Hematology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据