期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 72, 期 6, 页码 675-681出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2005.72.675
关键词
-
资金
- NIAID NIH HHS [R01 AI033656, R01 AI033656-11] Funding Source: Medline
Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. viva-V merozoite surface protein 1 (MSPI19), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据