期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 16, 期 6, 页码 880-882出版社
AMER CHEMICAL SOC
DOI: 10.1016/j.jasms.2005.01.015
关键词
-
资金
- NCRR NIH HHS [RR 018688] Funding Source: Medline
- NIAID NIH HHS [AI 33993] Funding Source: Medline
- NIGMS NIH HHS [GM 37537] Funding Source: Medline
Ion/ion reactions of multiply deprotonated peptide anions with xenon radical cations result in electron abstraction to generate charge-reduced peptide anions containing a free-radical site. Peptide backbone cleavage then occurs by hydrogen radical abstraction from a backbone amide N to facilitate cleavage of the adjacent C-C bond, thereby producing a- and x-type product ions. Introduction of free-radical sites to multiply charged peptides allows access to new fragmentation pathways that are otherwise too costly (e.g., lowers activation energies). Further, ion/ion chemistry, namely electron transfer reactions, presents a rapid and efficient means of generating odd-electron multiply charged peptides; these reactions can be used for studying gas-phase chemistries and for peptide sequence analysis. (c) 2005 American Society for Mass Spectrometry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据