期刊
TRENDS IN PARASITOLOGY
卷 21, 期 6, 页码 254-258出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2005.04.009
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- NIAID NIH HHS [AI05093] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.
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