期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 12, 期 6, 页码 554-555出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb939
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The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
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