期刊
CANCER AND METASTASIS REVIEWS
卷 24, 期 2, 页码 301-313出版社
SPRINGER
DOI: 10.1007/s10555-005-1579-7
关键词
nuclear factor-kappa B; melanoma; apoptosis; tumorigenesis; NF-kappa B inhibitors
类别
资金
- NCI NIH HHS [R01 CA034590, CA34590, R01 CA116021-01, CA56704, R01 CA116021, R01 CA116021-02] Funding Source: Medline
- BLRD VA [IK6 BX005225] Funding Source: Medline
Nuclear Factor-kappa B (NF-kappa B) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-kappa B activity has been shown to be upregulated in many cancers, including melanoma. Data indicate that the enhanced activation of NF-kappa B may be due to deregulations in upstream signaling pathways such as Ras/Raf, PI3K/Akt, and NIK. Multiple studies have shown that NF-kappa B is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasion, all of which indicate the important role of NF-kappa B in tumorigenesis. Thus, understanding the molecular mechanism of melanoma progression will aid in designing new therapeutic approaches for melanoma. In this review, the association between NF-kappa B and melanoma tumorigenesis are discussed. Additionally, the potential of emerging selective NF-kappa B inhibitors for the treatment of melanoma is reviewed.
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