期刊
EPILEPSY & BEHAVIOR
卷 6, 期 4, 页码 473-487出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2005.03.012
关键词
epilepsy; language; functional magnetic resonance imaging; plasticity
资金
- NINDS NIH HHS [K08 NS048063-01, K08 NS048063] Funding Source: Medline
This review addresses language function and reorganization associated with various forms of epilepsy. Longstanding epilepsy, particularly types with onset early in life, may be associated with changes in the representation of language function in the brain. As a result of this reorganization, language function may be relatively spared despite injury to areas of the brain that normally sub-serve these functions. We examine the changes seen in language function in two types of epilepsy: hemispheric epilepsy of childhood and focal epilepsies. Findings from behavioral studies, intracarotid amytal testing, intraoperative cortical testing, and more recent functional imaging studies are reviewed. Studying changes in the representation of language function seen in some forms of epilepsy provides information about brain plasticity with implications for other neurologic diseases, as well as for the neuroscientific understanding of how and when functional reorganization may occur. (c) 2005 Elsevier Inc. All rights reserved.
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