期刊
CURRENT OPINION IN CELL BIOLOGY
卷 17, 期 3, 页码 281-286出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.04.001
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- NIGMS NIH HHS [GM52581] Funding Source: Medline
Ribosomes, the large RNPs that translate mRNA into protein in the cytoplasm of eukaryotic cells, are synthesized in a subcompartment of the nucleus, the nucleolus. There, transcription by Pol I yields a pre-rRNA which is modified, cleaved and assembled with ribosomal proteins to make functional ribosomes. Previously, rRNA transcription and pre-rRNA cleavage in eukaryotes were considered to be separable steps in gene expression. However, recent findings suggest that these two steps in gene expression can be concurrent and are co-regulated. Unexpectedly, optimal rDNA transcription requires the presence of a defined subset of components of the pre-rRNA processing machinery.
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