期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 35, 期 6, 页码 733-740出版社
WILEY
DOI: 10.1111/j.1365-2222.2005.02254.x
关键词
allergy; atopic dermatitis; infant; risk factor; sensitization
Objective To evaluate the influence of perinatal environmental factors on early sensitization, atopic dermatitis and wheezing during the. first year. Methods Information on pregnancy-related factors, parental atopic history, environmental factors and the clinical course of the infant until age one was gathered by questionnaires, as part of a prospective birth cohort study (Prospective study on the Influence of Perinatal factors on the Occurrence of asthma and allergies [PIPO-study]). Quanti. cation of total and specific IgE was performed in 810 children and their parents. Results Early sensitization was found in 107/810 (13%) of the infants. Multiple regression analysis showed that specific IgE in fathers was a risk factor for early sensitization in their daughters ( adjusted odds ratios (ORadj) 2.21 (95% confidence interval (CI) 1.10 - 4.49); P=0.03), whereas in boys, day care attendance was shown to be protective for early sensitization (ORadj 0.38 (95% CI 0.20 - 0.71); P=0.001). Atopic dermatitis occurred in 195/792 infants (25%). Specific IgE in the mother (ORadj 1.52 ( 95% CI 1.06 - 2.19); P=0.02) and in the infant (ORadj 4.20 ( 95% CI 2.63 - 6.68); P < 0.001) were both risk factors for the occurence of atopic dermatitis, whereas postnatal exposure to cats was negatively associated with atopic dermatitis (ORadj 0.68 ( 0.47 - 0.97); P=0.03). Postnatal exposure to cigarette smoke (ORadj 3.31 ( 95% CI 1.79 - 6.09); P < 0.001) and day care attendance (ORadj 1.96 (95% CI 1.18 - 3.23); P=0.009) were significantly associated with early wheezing, which occurred in 25% (197/795) of the infants. Conclusion The effect of paternal sensitization and day care attendance on sensitization is gender dependent. Maternal sensitization predisposes for atopic dermatitis, whereas postnatal exposure to cats had a protective effect.
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