期刊
EUROPEAN JOURNAL OF NEUROLOGY
卷 12, 期 6, 页码 425-431出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1468-1331.2005.00936.x
关键词
glatiramer acetate; immunomodulating treatment; interferon-beta; multiple sclerosis; prospective open label study
A total of 308 patients with relapsing remitting multiple sclerosis (RRMS) documented in a clinical database have been analysed for comparison of treatment effects of first line immunomodulating therapies. During follow up for 24 months the reduction of relapse rates was evaluated in a retrospective and open-label clinical study by comparing the efficacy of interferon (INF)β-1a i.m. (Avonex(R)), INFβ-1b s.c. (Betaferon(R)), INFβ-1a 22 μ g s.c. (Rebif(R) 22) and glatiramer acetate (GA; Copaxone(R)) in patients with RRMS (enhanced disability status score (EDSS) < 3.5) who have been treated for at least 6 months. Compared with baseline, relapse rate was reduced to a comparable extend after 6 month treatment with all regimen. For all drugs the effect on the relapse rate was sustained over 24 months.. There was no superiority of one of the INFβ preparations concerning reduction of relapse rate after 12 and 24 months, however reduction was significantly higher for patients treated with GA compared with all beta interferons (-0.71, P < 0.001). In addition, the discontinuation rate within 24 months was significantly lower for GA. Despite some limitations of the study design, the results provide helpful clinical information regarding the efficacy of immunomodulatory therapies in early stages of RRMS patients in a clinical setting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据