期刊
FEMS MICROBIOLOGY LETTERS
卷 247, 期 1, 页码 73-79出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.04.028
关键词
Bacillus subtilis; replication initiation; negative regulator; flow cytometry
类别
It is shown here by flow cytometry that Bacillus subtilis YabA negatively regulates the timing of replication initiation. When the level of YabA was reduced, replication began at a decreased cell mass and when the level was increased, initiation was delayed. Synchrony of replication initiation was also disrupted at low levels of YabA. Yfp-YabA localized as foci in cells. Since YabA was reported to interact with DnaN (beta subunit of DNA polymerase III), co-localization of Yfp-YabA with the polymerase was examined using a Cfp fusion with DnaX (tau subunit of DNA polymerase III). It is reported that YabA appears to localize at the replication forks only at a late stage of DNA replication. (C) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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