期刊
INTERNATIONAL IMMUNOLOGY
卷 17, 期 6, 页码 815-825出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxh263
关键词
NF-kappa B; B-cells; lymphocytes; development; apoptosis
类别
资金
- NIAID NIH HHS [R37-AI33443, R37 AI033443] Funding Source: Medline
The regulation of the transcription factor nuclear factor-kappa B (NF-kappa B) during B-cell development was examined using cells isolated from the bone marrow of transgenic mice expressing a kappa B luciferase reporter gene. The results indicate that the highest level of NF-kappa B activity is present in cells expressing the pre-B-cell receptor. Furthermore, cross-linking of Ig beta on CD43(+) pre-B cells is able to activate NF-kappa B in recombination-activating gene 1-deficient mice, preceding their further differentiation into CD43(-) pre-B cells. Expression of a dominant negative form of I kappa B alpha using a transgenic approach or by retroviral infection leads to a reduction in the number of CD43(+) pre-B cells. These data therefore indicate that activation of NF-kappa B in CD43(+) pre-B cells, as a result of signaling by the pre-B-cell receptor, facilitates the continued development of large, CD43(+) pre-B cells into small CD43(-) pre-B cells.
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