期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 16, 期 3, 页码 265-278出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2005.04.002
关键词
TGF-beta; BMP; receptor; embryogenesis; gastrulation; embryonic patterning
Bone morphogenetic proteins (BMPs) play pleiotropic roles during embryonic development as well as throughout life. Recent genetic approaches especially using the mouse gene knockout system revealed that BMP signaling is greatly involved in early embryonic patterning, which is a dynamic event to establish three-dimensional polarities. The purpose of this review is to describe the diverse function of BMPs through different receptor signaling systems during embryonic patterning including gastrulation and establishment of the left-right asymmetry. (c) 2005 Elsevier Ltd. All rights reserved.
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