Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa

NGF is implicated in retinal damage regression. To Study whether this is a direct effect or an effect mediated by NGF oil other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, beta-fibroblast growth factor, transforming growth factor-beta, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina. (c) 2005 Elsevier Ltd. All rights reserved.