期刊
CURRENT OPINION IN IMMUNOLOGY
卷 17, 期 3, 页码 244-250出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.04.009
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资金
- NIAID NIH HHS [R01 AI014782] Funding Source: Medline
Marginal zone (MZ) B cells, together with other strategically located innate cells, constitute the first line of defense against blood-borne microorganisms, viruses and toxins in the spleen. Their fast and efficient protective antibody responses are well characterized; however, much less is known of their interactions with other cell types during immune responses. Recent work has demonstrated that MZ B cells can directly activate T cells; and MZ B cells also interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses.
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