期刊
BRITISH JOURNAL OF PLASTIC SURGERY
卷 58, 期 4, 页码 518-532出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjps.2004.12.012
关键词
biomaterials; subcutaneous implant; porcine; histological response; biocompatibitity
类别
This study assessed the suitability of Permacol (TM) (a porcine derived, isocyanate cross linked collagen based biomaterial.) as an alternative to autologous tissue in soft tissue reconstruction. The Sprague-Dawley rat was used as a model for subcutaneous implantation over a 20 week period and comparison made with two other porcine biomaterials (small intestinal submucosa and glycerol treated-ethylene oxide sterilised porcine dermis). Implants were scored histometrically on the degree of acute inflammation, chronic inflammation, fibrosis and stromal response. The vascularity and percentage composition of collagen within Permacol (TM) were assessed by stereology and seescan image analysis, respectively. In general. terms, Permacol (TM) was well tolerated as a subcutaneous implant, with only a minor chronic inflammatory response remaining after a 20 week period of implantation. There was evidence of collagen degradation during this period and vascular ingrowth into Permacol (TM) was limited. Permacol (TM) has the potential for a broad range of applications in plastic surgery, but may benefit from modification to promote a more rapid degree of vascularisation. (c) 2005 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.
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