期刊
TRENDS IN NEUROSCIENCES
卷 28, 期 6, 页码 334-340出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2005.04.002
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资金
- NIMH NIH HHS [MH54671] Funding Source: Medline
This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.
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