期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 49, 期 6, 页码 2536-2538出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.6.2536-2538.2005
关键词
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The role of Aspergillus fumigatus 14 alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.
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