期刊
AMERICAN JOURNAL OF SURGERY
卷 189, 期 6, 页码 707-713出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2005.03.012
关键词
rectal carcinoma; prognosis; venous invasion; lymphatic invasion
类别
Background: Surgery is considered curative in Dukes' B rectal cancer; however, many patients present with early relapse. To identify additional staging information, venous and lymphatic invasion were evaluated as potential prognostic factors. Methods: Patients with Dukes' B or C rectal disease treated between 1976 and 2001 at a single institution were compared. Patient and treatment characteristics and vascular invasion were documented. The impact of vessel invasion was determined using Cox proportional hazards model. Results: There were 256 Dukes' B patients and 74 Dukes' C cases without vascular invasion. Five-year survival was 76.5% for Dukes' B and 57.1% for Dukes' C patients. Vessel involvement increased the risk of recurrence (hazard ratio [HR] = 3.27, P =.0003) and death (HR = 3.11, P =.002) in 132 patients. The magnitude of these associations were comparable to that of C I patients for recurrence (HR = 2.81, P =.004) and death (HR = 3.05, P =.005), as well as C2 patients for recurrence (HR = 3.45, P =.0008) and death (HR = 3.87, P =.0005). Conclusion: Vascular invasion may be useful in characterizing patients with aggressive Dukes' B disease, who might benefit the most from adjuvant systemic therapy. (c) 2005 Excerpta Medica Inc. All rights reserved.
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