期刊
CLINICAL THERAPEUTICS
卷 27, 期 6, 页码 940-950出版社
ELSEVIER
DOI: 10.1016/j.clinthera.2005.06.006
关键词
diabetes mellitus; costs; budget impact; modeling; health economics
Objective: The aim of this study was to investigate the health-economic impact of maintaining glycosylated hemoglobin (HbA(1c)) values in all US patients with currently uncontrolled type 1 or type 2 diabetes mellitus at the American Diabetes Association (ADA) standard of 7.0% and the American Association of Clinical Endocrinologists (AACE) target of 6.5% compared with maintenance at current population-based values. Methods: The CORE-Center for Outcomes Research Diabetes Model was used to predict costs and outcomes for patients with uncontrolled type 1 and type 2 diabetes who remain at established population mean HbA(1c) values in comparison with those for patients who maintain the standard value of 7.0% or the target value of 6.5%. The analysis was run from a societal perspective over a 10-year time horizon. The costs of treating complications and medication costs were retrieved from published sources. Costs and clinical outcomes were discounted at 3% per annum. Sensitivity analyses were performed on the discount rate and time horizon. Results: This analysis found that maintaining HbA(1c) at the ADA standard value of 7.0% and the AACE target value of 6.5% in patients with uncontrolled type 1 and type 2 diabetes could achieve total direct medical cost savings of nearly $35 and $50 billion, respectively, over 10 years. When indirect cost savings were included, the total savings increased to between nearly $50 billion and $72 billion for these respective HbA(1c) targets, corresponding to 4% and 6% of the total annual US health care costs of $1.3 trillion. Reduced savings were observed with a higher discount rate and shorter time horizon, but savings increased as the time horizon became longer. These cost savings must be weighed against the cost of reaching the HbAlc goals and the likelihood of achieving the clinical objectives. Conclusions: Efficient targeting of financial resources toward the goal of lowering HbA(1c) in line with published guidelines could lead to financial savings in the range from nearly $35 billion to $72 billion over the next 10 years. Copyright (c) 2005 Excerpta Medica, Inc.
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